2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141369
    Bromo-PEG24-Boc
    Bromo-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG24-Boc
  • HY-138708
    Azido-PEG8-NHBoc 2231845-12-6
    Azido-PEG8-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG8-NHBoc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-NHBoc
  • HY-140971
    Mal-PEG12-alcohol
    Mal-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG12-alcohol
  • HY-140949
    N-(Biotin)-N-bis(PEG1-alcohol) 2100306-75-8
    N-(Biotin)-N-bis(PEG1-alcohol) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Biotin)-N-bis(PEG1-alcohol)
  • HY-168388
    Piperidine-C2-piperazine-Boc 2222119-35-7
    Piperidine-C2-piperazine-Boc is a PROTAC linker that can be used in the synthesis of PROTACs.
    Piperidine-C2-piperazine-Boc
  • HY-140399
    Aminooxy-PEG7-methane 1370698-27-3
    Aminooxy-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG7-methane
  • HY-140863
    PC-PEG11-Azide 2353409-89-7
    PC-PEG11-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PC-PEG11-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    PC-PEG11-Azide
  • HY-140072
    endo-BCN-PEG2-PFP ester 1421932-53-7
    endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-PFP ester
  • HY-141245
    Hydroxy-PEG4-C2-nitrile 2194563-83-0
    Hydroxy-PEG4-C2-nitrile is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-C2-nitrile
  • HY-140796
    Azido-PEG6-C1-Boc 297162-49-3
    Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-C1-Boc
  • HY-140466
    Fmoc-NH-PEG11-CH2COOH 2629308-66-1
    Fmoc-NH-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG11-CH2COOH
  • HY-140839
    Boc-NH-PEG7-azide 206265-96-5
    Boc-NH-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG7-azide
  • HY-130712
    NH2-C2-amido-C2-Boc 1692613-62-9
    NH2-C2-amido-C2-Boc is a PROTAC linker, which refers to the alkyl/ether composition. NH2-C5-NH-Boc can be used in the synthesis of a series of PROTACs, such as the PROTAC CDK2/9 Degrader-1 (HY-130709).
    NH2-C2-amido-C2-Boc
  • HY-138722
    Mal-PEG10-Boc
    Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG10-Boc
  • HY-156391A
    (R)-TCO4-PEG2-Maleimide
    TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    (R)-TCO4-PEG2-Maleimide
  • HY-140184
    Amino-PEG28-acid
    Amino-PEG28-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG28-acid
  • HY-138732
    m-PEG5-amino-Mal
    m-PEG5-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-amino-Mal
  • HY-141206
    Hydroxy-PEG11-Boc 3083093-64-2
    Hydroxy-PEG11-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG11-Boc
  • HY-173068
    2-(4-(Piperazin-1-yl)piperidin-1-yl)acetic acid
    2-(4-(Piperazin-1-yl)piperidin-1-yl)acetic acid is the linker that can be used for synthesis of PROTAC degrader NU227326 (HY-173066).
    2-(4-(Piperazin-1-yl)piperidin-1-yl)acetic acid
  • HY-140782
    Azido-PEG12-Boc
    Azido-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-Boc
PROTAC Linkers Isoform Comparison

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